Open-source software has arrived!

dcemriS4 is a package, written in the R programming environment, for the quantitative analysis of dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) for oncology applications. It has been released under the BSD license.

The scientific backbone of this software is based on research in the area of parameter estimation and statistical inference over several years. Three scientific publications outline the major techniques available:

An application of both the Bayesian and Frequentist methods to fit compartmental models to DCE-MRI data from a clinical trial may be found at

The dcemriS4 package provides a comprehensive set of R functions (subroutines) that perform all the necessary tasks to produce quantitative estimates of tumor perfusion/permeability using “standard” kinetic models. Data must be in one of two standard formats, Analyze or NIfTI, and results may be written out to either format. If your data are in DICOM format, then we suggest using oro.dicom in R or feel free to use one of the many OSS implementations that convert to Analyze or NIfTI.

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